Rhodium-Catalyzed C–H Alkylation of Indolines with Allylic Alcohols: Direct Access to β-Aryl Carbonyl Compounds

Abstract

The rhodium(III)-catalyzed site-selective C-H alkylation of various N-heterocycles, such as indolines, carbazoles, and pyrroles with readily available allylic alcohols is described. This protocol allows the generation of a heterocyclic scaffold containing a β-aryl carbonyl moiety, which is known to be a crucial structural unit of biologically active compounds.