Investigation of the biochemical evidence for the antiulcerogenic activity of Synclisia scabrida

Abstract

Objective: The antiulcerogenic activity of flavonoid (A) and alkaloid (B) fractions of the S. scabrida and their effect on alkaline phosphatase activity were studied. Methods: The ethanol extract of S. scabrida was subjected to a column and preparative thin layer chromatography to obtain partially pure fractions of A and B which were subjected to antiulcerogenic screening and effects on alkaline phosphatase activity using aspirin and 0.6N NaOH ulcer models. Results: The results showed that fractions A and B significantly (P<0.05) reduced both the ulcer index and alkaline phosphatase activity when compared with aspirin or 0.6N NaOH only. Conclusion: This study seems to implicate alkaline phosphatase as a biochemical evidence of the antiulceroragenic activity of S. scabrida.