Effects of propranolol on marihuana‐induced cognitive dysfunctioning

Abstract

Paid male volunteers were allowed to smoke marihuana cigarettes calibrated to deliver a dose of 25 µg per kilogram of delta‐9‐tetrahydrocannabinol (Δ‐9‐THC). All subjects were given propranolol or placebo (administered in a double‐blind fashion), in 4 divided doses beginning 24 hours before and ending 2 hours prior to smoking. Marihuana smoking resulted in significant disruption in the recall of narrative material and moderate impairment in performance on a modified version of the Reitan Trail Making test. Stroop‐Color Word performance was not affected by marihuana. Propranolol, a beta adrenergic blocking agent, failed to interact with marihuana to reduce its disruptive effects on any of the tests.