Topical Diclofenac Treatment Prior to Excimer Laser Photorefractive Keratectomy in Rabbits

Abstract

Topical administration of diclofenac reduces the release of PGE2 and the migration of polymorphonuclear leukocytes in the rabbit cornea 3 hours after 193-nanometer excimer laser ablation. However, pretreatment of the cornea, starting 2 hours prior to laser surgery, does not seem to offer advantages over postablation treatment in this animal model.