Concepedia

Prognostic Utility of Immunoprofiling in Colon Cancer: Results from a Prospective, Multicenter Nodal Ultrastaging Trial

Devin C. Flaherty, Simon Lavotshkin, John R. Jalas, Hitoe Torisu‐Itakura, Daniel D. Kirchoff, Myung‐Shin Sim, Delphine J. Lee, Anton J. Bilchik

Journal of the American College of Surgeons · 2016 · 28 citations · 21 references

DOI

Abstract

This is the first prospective demonstration of the prognostic utility of immunoprofiling in colon cancer after nodal ultrastaging. Staging based on tumor immunoprofile can augment TNM staging and provide targets for specific immunotherapies.

References

21

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Dung T. Le, Jennifer N. Uram, Hao Wang et al. · New England Journal of Medicine · 2015 · 9.2K citations · Full text

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Jérôme Galon, Anne Costes, Fátima Sánchez‐Cabo et al. · Science · 2006 · 6.3K citations

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Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

Franck Pagès, Anne Berger, Matthieu Camus et al. · New England Journal of Medicine · 2005 · 2.1K citations · Full text

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Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

Daniel J. Sargent, Silvia Marsoni, Geneviève Monges et al. · Journal of Clinical Oncology · 2010 · 1.6K citations · Full text

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

Yoshitaka Naito, Kazuya Saito, Kenichi Shiiba et al. · PubMed · 1998 · 1.2K citations

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