Concepedia

Publication | Open Access

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification

DOIFull Paper Access

440

Citations

56

References

2016

Year

Dan L. Li, Zhao V. Wang, Guanqiao Ding, Wei Tan, Xiang Luo, Alfredo Criollo, Min Xie, Nan Jiang, Herman I. May, Viktoriia Kyrychenko,
Circulation

Abstract

Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity.

References

YearCitations

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