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Performance characteristics of the right heart bypass preparation
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1960
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Cardiac AnaesthesiaSurgeryCircuit PressuresAnesthetic AdministrationBlood Flow MeasurementCardiologyAnesthetic PharmacologyCardiothoracic SurgeryAnimal PhysiologyAnesthesia PracticePump OutputCardiac CareCardiac SurgeryPhysiologyPulmonary PhysiologyPerformance CharacteristicsElectrophysiologyCardiovascular PhysiologyMechanical Self-regulationAnesthesiaMedicineAnesthesiology
In eight dogs under morphine-barbital anesthesia, the right ventricle was replaced by a sigmamotor pump in order to study steady-state responses of circuit pressures to arbitrary variations in ‘right heart’ output. In the systemic circuit, it was found that arterial pressure (P AS , mm Hg) was a positive and venous pressure (P VS , mm Hg) a negative function of pump output (Q, cc/min). In the pulmonary circuit, both arterial (P AP ) and left atrial (P LA ) pressures were positive functions of pump output. Despite considerable variations in detail between animals, individual animal pressure-flow curves could all be represented to a reasonable degree of approximation by linear functions within the range of the data. Average regression equations for the eight animals were: P AS = 18.3 + 0.0639Q, P VS = 20.2 – 0.0124Q, (P AS – P VS ) = 0.0756Q – 1.59 P AP = 11.2 + 0.0151Q, P LA = 7.0 + 0.00208Q, and (P AP – P LA ) - 3.9 + 0.0154Q. These results were interpreted in terms of a quantitative theory of mechanical self-regulation in the cardiovascular system.