Concepedia

Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation

Felix Perez, Andrew R. Waldeck, Michael J. Krische

Angewandte Chemie International Edition · 2016 · 24 citations · 64 references

DOIFull text

Open access

Concepts

Abstract

The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required.

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