Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S <i>LRRK2</i> carriers

Abstract

Elevated ratio of phosphorylated Ser-1292 LRRK2 to total LRRK2 in urine exosomes predicted LRRK2 mutation status and PD risk among LRRK2 mutation carriers. Future studies may explore whether interventions that reduce this ratio may also reduce PD risk.