Improved desorption/ionization and ion transmission in surface scanning by direct analysis in real time mass spectrometry

Abstract

The desorption strength, ionization efficacy and ion transmission were improved significantly giving increased detectability using this further modified DART-MS interface with reduced cap length and optimum transfer tube geometry. The resolution was comparable with state-of-the-art densitometry. With this setup, reliable HPTLC surface scanning is possible, even for substance amounts in the low-nanogram range.