Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats

Abstract

Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenacsodium has been entrapped in niosomes comprising Tween 85 and Tween 85-poloxamer F 108 mixture. Anti- inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:l combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.