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Myositis ossificans following forcible manipulation of the leg. A rabbit model for the study of heterotopic bone formation.
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1980
Year
EngineeringHeterotopic Bone FormationBone RepairRabbit ModelSurgeryBiomedical EngineeringOrthopedic BiomechanicsOrthopaedic SurgeryRegenerative MedicineBiomechanicsRight Hind LimbsBone RemodelingOsteoarthritisOrthopaedicsForty-four RabbitsBone HomeostasisJoint ReplacementMechanobiologyForcible ManipulationMusculoskeletal TissueSkeletal BiologyHuman Musculoskeletal SystemHuman Myositis OssificansMedicine
The right hind limbs of forty-four rabbits were immobilized with the knee in extension for as long as five weeks, except for a daily session of forcible mobilization lasting five minutes. Within five weeks there was progressive heterotopic-bone formation in the quadriceps muscle. The roentgenographic and histological changes were similar to those seen in human myositis ossificans.