Correlation between endothelin-1 and atherosclerosis in chronic hemodialysis patients

Abstract

In HD patients, the circulating levels of ET-1 and expression of ET-1 in internal iliac artery walls were statistically associated with CRP and IL- 6. Moreover, the circulating levels of ET-1 and expression of ET-1 in internal iliac artery walls were independent predictors of carotid atherosclerosis. The correlations may suggest that increased circulating ET-1 level and upregulated expression of ET-1 in the vasculature could contribute to the formation of atherosclerosis in HD patients.