Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Abstract

By employing a simple, inexpensive, and transition-metal-free oxidation system, secondary C-H bonds in a series of phthaloyl protected primary amines and amino acid derivatives were oxidized to carbonyls with good regioselectivities. This method could also be applied to oxidize tertiary C-H bonds and modify synthetic dipeptides.