Glutamate mGlu5-adenosine A2A-dopamine D2 receptor interactions in the striatum. Implications for drug therapy in neuro-psychiatric disorders and drug abuse

Abstract

Chloroquine (CQ) resistance is a serious problem afflicting the populations in the Third World countries where malaria is endemic. Some strategies have been developed to circumvent the increasing spread of CQ resistance and the alarming emergence of multidrug resistance in malaria. Among these, drug combination has received much attention in the past few years. In this approach, the sensibility of resistant malaria parasites to antimalarial drugs can be restored by coadministration of one of the drugs collectively named reversing agents or chemosensitizers. The present review gives a update of chemically synthetized and naturally occuring reversing agents that have been proved to potentiate in vitro and/or in vivo the effect of the existing antimalarial drugs