Concepedia

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression

Sandra M. Lopez, Alexander I. Agoulnik, Manqi Zhang, L. E. Peterson, Egla Suarez, Gregory A. Gandarillas, Anna Frolov, Rile Li, Kimal Rajapakshe, Christian Coarfa,

Clinical Cancer Research · 2016 · 25 citations · 50 references

DOIFull text

Open access

Abstract

In summary, we demonstrated that NCOR1 function declines with prostate cancer progression. Reduction in NCOR1 levels causes bicalutamide resistance in LNCaP cells and compromises response to bicalutamide in mouse prostate in vivo Clin Cancer Res; 22(15); 3937-49. ©2016 AACR.

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