Concepedia

Tapering and discontinuation of methotrexate in patients with RA treated with TNF inhibitors: data from the DREAM registry

S. Manders, Mart A F J van de Laar, Sanne A A Rongen-van Dartel, Reinhard Bos, Henk Visser, Herman L. M. Brus, Tim Jansen, Harald E. Vonkeman, Piet L. C. M. van Riel, Wietske Kievit

RMD Open · 2015 · 12 citations · 18 references

DOIFull text

Open access

Abstract

In daily practice, tapering or discontinuation of concomitant MTX in patients with RA treated with TNFi frequently occurs and it does not seem to influence the average DAS28 over time or the long-term TNFi drug survival. It appears that in daily clinical practice the correct patients are selected to taper or discontinue MTX.

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