Macromolecular Bioscience · 2016 · 43 citations · 47 references
PharmacyMaterials SciencePharmaceuticsDrug DeliveryNanomaterialsNanoparticle Drug DeliveryControlled Release MechanismsNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle FormulationsPh-responsive Drug DeliveryAcid StimulationDrug Delivery NanocarriersDrug Release MechanismsMesoporous Silica NanomaterialsMesoporous Silica NanoparticlesNanoparticle-based Controlled ReleasePh-sensitive NanoparticlesSilica-based Nanoparticles
A visible light and pH responsive anticancer drug delivery system based on polymer-coated mesoporous silica nanoparticles (MSNs) has been developed. Perylene-functionalized poly(dimethylaminoethyl methacrylates) sensitive to visible light and pH are electrostatically attached on the surface of MSNs to seal the nanopores. Stimulation of visible light and acid can unseal the nanopores to induce controlled drug release from the MSNs. More interestingly, the release can be enhanced under the combined stimulation of the dual-stimuli. The synergistic effect of visible light and acid stimulation on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.
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MCM-41 Organic Modification as Drug Delivery Rate Regulator
B. Muñoz, A. Rámila, Joaquín Pérez‐Pariente et al. · Chemistry of Materials · 2002 · 615 citations