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Human pharmacology and clinical evaluation of an oral carbenicillin preparation
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1971
Year
Healthy SubjectsUrinary Tract InfectionPharmacotherapyAntimicrobial ChemotherapyDrug ResistancePharmacological StudyAntimicrobial StewardshipHuman PharmacologyToxicologyDrug MonitoringClinical ChemistryAntimicrobial ResistanceTherapeutic Drug MonitoringOral CarbenicillinAntimicrobial PharmacokineticsPharmacologyAntibioticsClinical PharmacologyAntimicrobial PharmacodynamicsMedicinePharmacokineticsDrug DiscoveryDrug Analysis
Oral carbenicillin was administered to 6 healthy subjects and to 28 patients with urinary tract infection. Following a 1 Gm. dose, the mean peak serum concentration was 10.4 µg per milliliter. Urine concentrations ranged from 640 to 2,560 µg per milliliter during the first 6 hours. Probenecid increased the mean peak serum level to 23.7 µg per milliliter. Symptoms disappeared during the first 72 hours and the infecting organism was eliminated from all. Four weeks after discontinuing therapy 16 patients (57 per cent) were abacteriuric and 4 relapsed within 4 weeks, while 8 became reinfected with a new organism. Because of severe nausea and vomiting after ingestion of the drug, 3 patients were dropped from the study.