Glycomapping the fine specificity of monoclonal and polyclonal Lewis antibodies with type‐specific Lewis kodecytes and function‐spacer‐lipid constructs printed on paper

Abstract

Substantial cross-reactivity of both MoAbs and PoAbs with related antigens highlights the risks of using serologic reagents in nonserologic assays or against synthetic antigens. The lack of ALe(b) activity in anti-Le(b) MoAbs explains their poor performance against blood group A1 Le(a-b+) phenotypes.