Retinoic Acid: Enhancement of a Tumor and Inhibition of Interferon's Antitumor Action<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

Abstract

The effect of trans-retinoic acid on the growth of P388 lymphoid tumors in inbred female DBA/2 mice in the presence or absence of interferon (FN) treatment was studied. This acid derivative of vitamin A enhanced local tumor growth. trans-retinoic acid also partially reversed IFN protection against tumor growth and mortality.