Erythema Dyschromicum Perstans Response to Isotretinoin

Abstract

of cutaneous cancers; the addition of voriconazole appears to accelerate UV-induced skin damage. 5While our patient had been on a long-term treatment regimen of low-dose corticosteroids, she was relatively immunocompetent, suggesting that immunocompetent individuals may also be at risk for photocarcinogenic effects of voriconazole. 6 Posaconazole appears to have a more favorable adverse effect profile than voriconazole. 3 In a case series of 3 patients with voriconazole-associated SCC, posaconazole was replaced in 2 of 3 patients, with improvement of the photosensitivity reaction. 6 While the present patient did not cease developing SCCs, tumor burden and quality of life improved.Considering that posaconazole has a favorable adverse effect profile, it should be considered more often for patients who are at risk of cutaneous cancer development.