Formulation and Evaluation of Fast Dissolving Oral Films of Zolmitriptan

Abstract

The present study was aimed to formulate and evaluate fast dissolving oral films of Zolmitriptan using sodium alginate, xanthan gum and sodium starch glycolate, guar gum. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting method and characterized by UV, FTIR studies. The films were evaluated for disintegration time, Folding endurance, Tensile Strength, Mouth dissolving time, Thickness, content uniformity and In-vitro dissolution studies. The F 5 formulation has given 98.5% drug release within 6 minutes and has a tensile strength of 1.80 MPa.