Heparin reduces glomerular infiltration and TGF-beta protein expression by macrophages in puromycin glomerulosclerosis. - Concepedia

Concepedia

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Heparin reduces glomerular infiltration and TGF-beta protein expression by macrophages in puromycin glomerulosclerosis.

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References

2003

Year

Monica Ceol, Daniela Vianello, Erwin Schleicher, Franca Anglani, Miriam Barbanti, Luciana Bonfante, Giselda Bertaglia, Romina Graziotto, Angela D’Angelo, Dorella Del Prete,

Abstract

The inhibition of TGF-beta in macrophages seems to be part of heparin general activities. The inhibitory effect of heparin on macrophage infiltration and TGF-beta synthesis in this renal disease model supports the notion that heparin and derived molecules constitute potentially useful therapeutic agents in nephropathies.