New England Journal of Medicine · 1958 · 62 citations · 64 references
Health ProfessionsOrthopaedic SurgeryOrthopedic SurgeryNeuropathic Foot DisordersOrthopedicsWound HealingDiabetic Foot SurgeryDiabetic Foot UlcerationFoot UlcerationUlcer ManagementWound AssessmentWound CareCustom-made FootwearFoot Ulcer HealingNeuropathic Ulcer ManagementPostoperative Wound HealingWound Healing Measurement
THE significance of studies on abnormal wound healing resides mainly in their delineation of some of the essential features of normal repair. pharmacologic, species and other experimental variables in such investigations make their interpretation difficult and their application to the metabolic processes of health and disease in man somewhat speculative. Among the conditions that cause defective wound healing two naturally occurring diseases, scurvy and protein starvation, have been the most widely investigated.nutritional DeficienciesAscorbic AcidOnly the guinea pig, primates and man are known to require dietary vitamin C and to suffer from scurvy in its absence. Although ascorbic . . .
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John H. Crandon, Charles C. Lund, D. B. Dill · New England Journal of Medicine · 1940 · 396 citations
Bernard S. Gould, J. Frederick Woessner · Journal of Biological Chemistry · 1957 · 215 citations · Full text