Effect of cholesterol content and surfactant HLB on vesicle properties of niosomes

Abstract

Effect of cholesterol content on entrapment efficiency and influence of surfactant HLB on the vesicle size has been studied on sorbitan esters vesicles also known as nicsomes prepared using a mechanical shaking technique without sonication. Primaquine phosphate was used as a model drug. Entrapment efficiency increased with Increasing cholesterol content. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from Span 85 (HLB 1.8) to Span 20 (HLB 8.6).