Publication | Closed Access
Discovery of monocarbonyl curcumin hybrids as a novel class of human DNA ligase I inhibitors: in silico design, synthesis and biology
16
Citations
50
References
2016
Year
Hligi InhibitorsChemoprevention StrategyMolecular BiologyPharmacotherapyChemical BiologyPharmaceutical ChemistryHuman Dna LigaseMolecular PharmacologyMedicinal ChemistryAnti-cancer AgentPharmacophore ModelMonocarbonyl Curcumin HybridsInhibitory ActivityBiochemistryOligonucleotideMechanism Of ActionNovel ClassPharmacologyNatural Product SynthesisNatural SciencesSynthetic BiologySilico DesignMedicineGenome EditingDrug Discovery
A pharmacophore model identified a novel class of hLigI inhibitors to treat cancer. 36 compounds were synthesized and the identified inhibitor, compound<bold>23</bold>shown antiligase activity at IC<sub>50</sub>24.9 μM by abolishing the interaction between hLigI and DNA.
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