Targeting of micro<scp>RNA</scp>‐199a‐5p protects against pilocarpine‐induced status epilepticus and seizure damage via <scp>SIRT</scp>1‐p53 cascade

Abstract

The results of this study suggest that silencing of miR-199a-5p exerts a seizure-suppressing effect in rats, and that SIRT1 is a direct target of miR-199a-5p in the hippocampus. The effect of miR-199a-5p on seizures and seizure damage is mediated via down-regulation of SIRT1. The miR-199a-5p/SIRT1 pathway may thus represent a potential target for the prevention and treatment of epilepsy and epileptic damage.