No association between haplotypes of three variants (codon 81, 284, and 762) in poly(ADP-ribose) polymerase gene and risk of primary lung cancer.

Abstract

DNA repair plays a critical role in protecting the genome from the insults of cancer-causing agents, such as those found in tobacco smoke. Reduced DNA repair capacity can increase the susceptibility to lung cancer [(1)][1] . Polymorphisms in the DNA repair genes may alter the efficiency of DNA