Wound healing potential of green synthesized silver nanoparticles prepared from <i> Lansium domesticum</i> fruit peel extract

Abstract

Silver nanoparticles (AgNPs) are proved to be potential wound healing materials for normal and burn related wounds due to their antibacterial and antifungal properties. Although, the wound healing properties of AgNPs through green synthesis were less reported. In the present study, green synthesized AgNPs were incorporated in Pluronic F127 gels as a delivery system to evaluate their wound healing potentiality. Interestingly, the wound healing activity of 0.1% w/w (AgNPs) in Pluronic F127 gels was enhanced to a considerable extent which could be corroborated by increased amount of hydroxylproline content (2.39 ± 0.28 μg/mL), wound tensile strength (33.41 ± 2.38 N/cm2, and wound closure time, which were quite higher than other treated groups. Histopathology and biochemical tests did not show any inflammation, however, the amount of collagen production was increased in the group treated by 0.1% w/w AgNPs in Pluronic F127 gels.