<scp>d</scp>‐Penicillamine modulates hydrogen sulfide (<scp>H₂S</scp>) pathway through selective inhibition of cystathionine‐γ‐lyase

Abstract

Taken together, our results suggest that D-penicillamine acts as a selective CSE inhibitor, leading to new perspectives in the design and use of specific pharmacological tools for H2 S research. In addition, the inhibitory effect of D-penicillamine on CSE could account for its beneficial action in rheumatoid arthritis patients, where H2 S has been shown to have a detrimental effect.