Case Reports in Oncology · 2016 · 13 citations · 13 references
MedicineOncologyPharmacotherapyChemotherapyGastrointestinal OncologyMetastasisAscites ManagementHepatobiliary CancerLiver DiseaseLiver MetastasisMalignant NeoplasmsMetastatic Gastrointestinal CancerHepatic MalignancyLiver Metastases ManagementLiver Metastases TreatmentMalignant AscitesMetastatic Gastric CancerMetastatic Liver Disease TreatmentMetastatic Liver TumorsTotal Serum Bilirubin
We present the first reported case of pseudocirrhosis arising after a dramatic response to chemotherapy in metastatic gastric cancer. A 74-year-old man was diagnosed with gastric adenocarcinoma having multiple liver metastases. His general condition was poor, with an Eastern Cooperative Oncology Group performance status of 3, inadequate oral intake, and jaundice (total bilirubin 2.8 mg/dl). Chemotherapy with oxaliplatin, l-leucovorin, and 5-fluorouracil (modified FOLFOX-6) was initiated. After four treatment cycles, he experienced a marked regression of liver metastases; however, he developed massive ascites with a lobular liver surface and segmental atrophy, which were consistent with pseudocirrhosis. Chemotherapy was continued along with ascites management. Thereafter, ascites disappeared, and a complete response of the metastatic lesions was achieved at 11 months after initial treatment. He had no evidence of disease progression at 30 months after initial chemotherapy. This report suggests clinicians should recognize this entity, even in gastric cancer metastatic to the liver.
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Chemotherapy induced liver abnormalities: an imaging perspective
Ankush Sharma, Roozbeh Houshyar, Priya Bhosale et al. · Clinical and Molecular Hepatology · 2014 · 100 citations · Full text