Synthesis and Biological Evaluation of Some New Substituted Fused Pyrazole Ring Systems as Possible Anticancer and Antimicrobial agents

Abstract

This research work describes the synthesis and biological properties of some novel polysubstituted fused heterocyclic ring systems namely; pyrano(4,3-c) pyrazoles and pyrazolo(4,3- c)pyridines. Such targeted compounds where designed so as to hybridize the pyrazole ring with the pyrone and/or pyridine moieties, respectively, hoping to obtain synergistic anticancer and/or antimicrobial activities. The chemistry of the reactions employed in the synthesis of the target compounds together with their chemical behaviour, are discussed and the structures of the newly synthesized compounds were confirmed by the IR and 1 H-NMR spectral data. All the synthesized compounds showed weak anticancer activity according to the protocol of the National Cancer Institute (NCI), Maryland, USA. Additionally, they showed weak antimicrobial activity against some bacteria and fungi.