EVALUATION OF MILTEFOSINE AGAINST LEISHMANIA MAJOR (MRHO/IR/75/ER): IN VITRO AND IN VIVO STUDIES

Abstract

against Leishmania species and it was demonstrated efficacy in animals via the oral route. This study is the first one for evaluating the effect of miltefosine on cutaneous leishmaniasis of L. major (MRHO/IR/75/ER) by in vivo and in vitro studies in the BALB/c mouse model. As it was shown, miltefosine has a better effect on reduction of size of lesion compared to Glucantime®, also it was not significant by statistical analysis. The results of this study show that miltefosine has a good activity against the proliferation of amastigotes of L. major. The results suggest that oral miltefosine might be a promising approach for developing new anti-Leishmanial drugs.