Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population

Abstract

The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately.