Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in<i>Mybpc3</i>-targeted HCM mouse model

Abstract

These data provide evidence that in the KI HCM mouse model, β-AR stimulation leads to preferential PKA phosphorylation of PLN over cTnI, resulting in an impaired inotropic and lusitropic response.