PubMed · 1992 · 220 citations · 0 references
MedicineNuclear MedicineRadiologyDiagnostic RadiologyOncologic ImagingOncologic Nuclear MedicineCancer DetectionMalignant NeoplasmsOncologic Nuclear ImagingPositron Emission TomographyTumor CharacterizationTumor Imaging18F-fluorodeoxyglucose Imaging18F-fluorodeoxyglucose Positron Emission TomographyCell Cycle ImagingContrast RatioFluorine-18 Fluorodeoxyglucose Positron Emission TomographyMitotic Count EvaluationOncologic Pet ImagingPet Quantification
To evaluate the relationship between PET using 18F-fluorodeoxyglucose (FDG) and pathological findings and to compare indices obtained by FDG-PET, FDG-PET was performed in 23 patients with untreated malignant lymphoma. Three indices obtained by FDG-PET, tumor-to-normal contrast ratio (TCR), distribution absorption ratio (DAR), k1k2/(k2 + k3), correlated with proliferative activity which was pathologically estimated both by mitotic count and by proportion of cells in all phases of the cell cycle. The relationship did not significantly change according to which of the three indices was chosen. FDG-PET, which shows the proliferative activity of tumors, is considered to be a useful method for managing tumors.