Synthesis of benzo[1,3]oxazines via copper(<scp>i</scp>)-catalyzed cascade annulation of nitriles, aldehydes and diaryliodonium salts

Abstract

A copper(<sc>i</sc>)-catalyzed one-pot [2 + 2 + 2] cascade annulation reaction of diaryliodoniums, nitriles, and aldehydes has been developed for the efficient synthesis of 2,4-substituted benzoxazine derivatives.