Design and Synthesis of 2‐Methyl‐7‐aminobenzoxazole as Auxiliary in the Palladium(II)‐Catalyzed Arylation of a <i>beta</i>‐Positioned C(<i>sp</i>³)H Bond

Abstract

Abstract A palladium(II)‐catalyzed direct arylation of methylene C( sp 3 )H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta ‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%. magnified image