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Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate.

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Citations

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References

1994

Year

Hisashi Shinozuka, Yutaka Kubo, Katyal Sl, Pierpaolo Coni, Ledda-Columbano Gm, Amedeo Columbano, Takafumi Nakamura
PubMed

Abstract

Stimulation of hepatocyte proliferation induced by lead nitrate was not accompanied by changes in liver levels of HGF, TGF-alpha, or TGF-beta 1 mRNA. Lead nitrate, however, enhanced expression of TNF-alpha at a time preceding the onset of hepatocyte DNA synthesis, indicating that TNF-alpha may trigger the lead nitrate-induced proliferation of hepatocytes.