Propofol in emulsion form: induction characteristics and venous sequelae.

Abstract

Propofol in a 1% emulsion was used to induce anaesthesia in 20 female patients premedicated with diazepam (10 mg). A dose of 2.5 mg kg-1 produced a rapid loss of consciousness and only minor excitatory effects. Discomfort during the injection was not severe. Cardiovascular changes included a fall in blood pressure similar to that which occurs with other induction agents, and a decrease in pulse rate. Apnoea occurred after each induction and in some patients (13) was prolonged (greater than 60 s). There were no venous sequelae, and patient acceptance was high. Propofol given in an emulsion to induce anaesthesia merits further study.