Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants

Abstract

Fast dissolving tablets of Lisinopril were designed using combination of synthetic superdisintegrants like croscarmellose sodium, crospovidone and sodium starch glycolate in a ratio of 5:10 and 10:5 respectively by direct compression method. The blends of all formulations were evaluated for various pre-formulation factors. Tablets were evaluated for weight variation, hardness, disintegration time, drug content, friability and in vitro dissolution. The formulation of Lisinopril containing 10% crospovidone and 5% croscarmellose showed disintegration time of 145±0.502 secs respectively with 99% drug release within 30 mins. The results showed that super disintegrants used in combinations shows better disintegrating property. The FTIR spectra showed no interactions among them.