Induction of Hamster Tumors of the Urinary Bladder by 3,2′-Dimethyl-4-Aminobiphenyl<xref ref-type="fn" rid="FN2">2</xref>

Abstract

3,2′-Dimethyl-4-aminobiphenyl (3,2′-DMAB) was administered subcufaneously in doses of 100 mg/kg body weight to Syrian golden hamsters. Of 20 hamsters that lived over 158 days, 15 (12 females, 3 males) developed bladder tumors. In addition, 2 adenocarcinomas of the colon, 1 malignant lymphoma, 2 mammary carcinomas, 4 granulosa-theca cell tumors of the ovaries, and 1 squamous cell carcinoma of the skin were found. The mean cumulative doses and days required for the induction of bladder tumors were 2,400–2,700 mg/kg body weight (360–405 mg/animal) and 260–310 days. We believe this to be the first report of the induction of bladder tumors in Syrian golden hamsters by 3,2′;-DMAB.