The Effect of Light Exposure on the Efficacy and Safety of Amphotericin B in Corneal Storage Media

Abstract

In this study, Optisol-GS supplemented with a 0.255-μg/mL concentration of amphotericin B effectively eliminated fungal contaminants within 48 hours and did not result in added toxic effects to the cornea. These results do not prove that amphotericin B should be added to Optisol-GS; larger-scale studies and cost-benefit analyses need to be completed. Given the increasing incidence of postkeratoplasty fungal infection, however, the addition of amphotericin B to Optisol-GS deserves further investigation.