A chemical susceptibility profile of the<i>Plasmodium falciparum</i>transmission stages by complementary cell-based gametocyte assays

Abstract

This work indicates that the luciferase and gametocyte LDH assays are interchangeable and that their specific advantages can be exploited to design an HTS pipeline leading to new transmission-blocking compounds. Results from these assays consistently defined a gametocyte chemical susceptibility profile, relevant to the planning of future drug discovery strategies.