Publication | Closed Access
Palladium‐Catalyzed C(sp<sup>3</sup>)−H Functionalization at the C3 Position of <scp>l</scp>‐Pipecolinic Acid Derivatives
37
Citations
57
References
2016
Year
EngineeringOrganic ChemistryAcyloxylation ReactionsChemistryPharmaceutical ChemistryChemical EngineeringMedicinal ChemistryDiversity Oriented SynthesisOrganometallic CatalysisStereoselective SynthesisPd‐catalyzed ArylationDiversity-oriented SynthesisCompound 10CatalysisPharmacologyCatalytic SynthesisNatural SciencesMolecular CatalysisSynthetic ChemistryC3 Position
Abstract The study of Pd‐catalyzed arylation, alkoxylation, and acyloxylation reactions at the C3 position of l ‐pipecolinic acid derivatives to afford cis ‐disubstituted piperidines as single stereoisomers was performed. To demonstrate the utility of the reaction, compound 10 , an analogue of (−)‐3S‐3‐PPP ( 9 ) that is used as a neuroleptic drug for the treatment of schizophrenia, was synthesized featuring the arylation and radical decarboxylation reactions as key steps.
| Year | Citations | |
|---|---|---|
Page 1
Page 1