Concepedia

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Konrad Gabrusiewicz, Benjamin A.T. Rodriguez, Jun Wei, Yuuri Hashimoto, Luke M. Healy, Sourindra N. Maiti, Ginu Thomas, Shouhao Zhou, Qianghu Wang, Ahmed Elakkad,

JCI Insight · 2016 · 454 citations · 61 references

DOIFull text

Open access

Concepts

Abstract

cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.

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61

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Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

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