Silencing the porcine iGb3s gene does not affect Gal<i>α</i>3Gal levels or measures of anticipated pig‐to‐human and pig‐to‐primate acute rejection

Abstract

Our data suggest that iGb3s is not a contributor to antibody-mediated rejection in pig-to-primate or pig-to-human xenotransplantation. Although iGb3s gene silencing significantly changed the renal glycosphingolipid profile, the effect on Galα3Gal levels, antibody binding, and cytotoxic profiles of baboon and human sera on porcine PBMCs was neutral.