Splenic Macrophages in Thrombocytopenia

Abstract

Abstract Electron microscopic examination of splenic tissue obtained from patients with a variety of hematologic disorders has shown ultrastructural evidence for platelet breakdown within splenic histiocytes in seven out of eight patients with idiopathic thrombocytopenic purpura (I. T. P.). The morphologic characteristics of this intracellular digestion have been described.