Gold(I)-Catalyzed Cyclization/Nucleophilic Substitution of 1-(<i>N</i>-Sulfonylazetidin-2-yl) Ynones into <i>N</i>-Sulfonylpyrrolin-4-ones

Abstract

Polysubstituted pyrrolin-4-ones have been efficiently synthesized from readily available 1-(N-sulfonylazetidin-2-yl) ynones via gold(I)-catalyzed cyclization/nucleophilic substitution in the presence of various nucleophiles, such as water, alcohols, or indoles. Additionally, 3-iodopyrrolin-4-one derivatives have also been obtained under the same reaction conditions upon addition of 1.2 equiv of N-iodosuccinimide.